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It was also the tipping point for the man who would ultimately help bring him down

[1] [4] This is particularly relevant for patients taking additional glucose-lowering medications

July 2022

Inhibition of xCT by Class 1 ferroptosis inducers, such as erastin, may induce ferroptotic cell death mainly by depletion of cellular GSH content, and subsequently lead to inactivation of glutathione peroxidase-4 (GPX4

These sensors provide a readout of the subcellular redox environment by equilibrating with local GSH:GSSG pools and registering thiol redox changes via disulfide bond formation